Key result
Lethal and viability-restoring compensatory amino acid substitutions modulate the thermostability of the foot-and-mouth disease virus capsid, guiding recombinant vaccine development.
These findings provide new guidelines for the development of thermostabilized empty capsid-based recombinant vaccines against foot-and-mouth disease.
This study provides novel insights into the little-known structural determinants of the balance between thermal stability and instability in the capsid of foot-and-mouth disease virus and into the relationship between capsid stability and virus infectivity. The results provide new guidelines for the development of thermostabilized empty capsid-based recombinant vaccines against foot-and-mouth disease, one of the economically most important animal diseases worldwide.
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López-Argüello et al. (2019) studied this question. Lethal and viability-restoring compensatory amino acid substitutions modulate the thermostability of the foot-and-mouth disease virus capsid, guiding recombinant vaccine development.
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