Why the study?
Does oral treatment with an angiotensin receptor antagonist improve baroreflex function in rats with myocardial infarction?
Population
Conscious Wistar-Kyoto and spontaneously hypertensive rats whose left anterior descending artery had been…
Comparison
3-week oral treatment with the angiotensin II… vs Vehicle treatment
Design
Preclinical
Follow-up
3 weeks
Authors
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ARB may improve baroreflex gain post-MI in hypertensive rats; leaves open translation to human hypertension or heart failure outcomes.
Does oral treatment with an angiotensin receptor antagonist improve baroreflex function in rats with myocardial infarction?
Oral treatment with an angiotensin receptor antagonist restores impaired baroreflex function caused by myocardial infarction in a rat model.
Nishizawa et al. (1997) studied this question.