Key result
Current diagnosis and treatment strategies for pediatric pulmonary arterial hypertension remain largely derived from adult data, highlighting the need for adapted pediatric clinical studies.
Why the study?
Pediatric pulmonary arterial hypertension remains a rare and severe disease with no cure, and adapted clinical studies to define the best therapeutic approach are needed.
This review highlights the current diagnostic and therapeutic strategies for pediatric PAH, emphasizing the need for pediatric-specific clinical studies.
Answers are grounded in this paper and cite their sources.
Improved pediatric PAH outcomes support targeted therapies in practice; leaves open optimal long-term diagnostic and treatment strategies.
INTRODUCTION: Pediatric pulmonary arterial hypertension (PAH) remains a rare and severe disease with a poor prognosis. PAH may be idiopathic, heritable or associated with systemic conditions in particular associated with congenital heart disease. Areas covered: A thorough and extensive diagnostic approach is required for a correct diagnosis. The outcome has improved over the last decade with a better diagnostic approach and with the initiation of new targeted therapies. However, there is still significant progress to achieve as there is still no cure for this devastating disease. Expert opinion: Adapted clinical studies to define the best therapeutic approach are needed. Even if the treatment approach is still mainly derived from adult data and expert consensus, several studies and registries are currently underway and should deliver important information in the next future. This review aims to give an overview of the current diagnosis and treatment strategies of PAH.
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Farhat et al. (2019) conducted a review in Pediatric pulmonary arterial hypertension. Diagnosis and treatment strategies was evaluated. Current diagnosis and treatment strategies for pediatric pulmonary arterial hypertension remain largely derived from adult data, highlighting the need for adapted pediatric clinical studies.
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