Key result
Normal LDL-c levels greater than 1.51 mmol/L were non-linearly and positively associated with an increased risk of nonalcoholic fatty liver disease in non-obese Chinese individuals (OR 1.79).
Why the study?
Evidence regarding the relationship between normal low-density lipoprotein cholesterol levels and non-alcoholic fatty liver disease was limited in the non-obese Chinese population.
Is higher normal LDL-c associated with an increased risk of nonalcoholic fatty liver disease in a non-obese Chinese population?
Cross-Sectional (n=183,903)
No
Is higher normal LDL-c associated with an increased risk of nonalcoholic fatty liver disease in a non-obese Chinese population?
In non-obese Chinese individuals, LDL-c levels within the normal range are positively and non-linearly associated with an increased risk of NAFLD when LDL-c exceeds 1.51 mmol/L.
Answers are grounded in this paper and cite their sources.
Normal-range LDL-c may flag NAFLD risk in non-obese adults; leaves open causality and need for longitudinal confirmation.
Abstract Background Evidence regarding the relationship between normal low-density lipoprotein cholesterol (LDL-c) levels and non-alcoholic fatty liver disease (NAFLD) was limited. Therefore, this dissertation seeks to investigate the relationship between LDL-c and NAFLD in the non-obese Chinese population after adjusting for other covariates. Methods The present study was a cross-sectional study. A total of 183903 non-obese participants were involved in a Wenzhou Medical Center of Wenzhou People’s Hospital from 2010 to 2014. The target independent variable and the dependent variable were LDL-c measured at baseline and NAFLD respectively. Covariates involved in this study included SEX, AGE, BMI, SBP, DBP, FPG, ALB, ALT, AST, BUN, Cr, TG, TC, HDL-c, UA. It was noted that the entire study was completed by Dan-Qin Sun et al., and uploaded the data to the DATADRYAD website. The author only used this data for secondary analysis. Results The average age of 183903 selected participants was 41.0 ± 14.1 years old,and about 49.6% of them was male. After adjusting potential confounders (SEX, AGE, BMI, FPG, ALB, GLB, ALT, AST, GGT, BUN, Cr, TG, TC, HDL-c, UA), non-linear relationship was detected between normal LDL-c levels and NAFLD, whose point was 1.51. The effect sizes and the confidence intervals on the left and right sides of inflection point were 0.87 (0.64, 1.18) and 1.79 (1.67, 1.92), respectively. Conclusion The relationship between normal LDL-c levels and NAFLD is non-linear. Normal LDL-c levels was positively correlated with NAFLD when LDL-c was more than 1.51.
No takes yet. Share an insight, caveat, or question.
Xu et al. (2020) conducted a cross-sectional in Nonalcoholic fatty liver disease (NAFLD) (n=183,903). Normal LDL-c levels (≥1.51 mmol/L) vs. Normal LDL-c levels (<1.51 mmol/L) was evaluated on Nonalcoholic fatty liver disease (NAFLD) (OR 1.79, 95% CI 1.67, 1.92, p=<0.0001). Normal LDL-c levels greater than 1.51 mmol/L were non-linearly and positively associated with an increased risk of nonalcoholic fatty liver disease in non-obese Chinese individuals (OR 1.79).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: