Observations on tissue glycolysis

THE substances whose action will be described are mainly: (1) the ammonium ion, (2) glutamic acid and (3) maleic acid. They affect tissue glycolysis in different ways: either, as with (1), by raising the aerobic glycolysis and at the same time depressing anaerobic glycolysis, or, as with (2), mainly by inhibiting anaerobic glycolysis, or, as with (3), by a slow and continuous rise of the aerobic glycolysis to the normal level of the anaerobic glycolysis. The observed effects only occur or are specially pronounced in brain tissue.