Global spatiotemporal transmission patterns of human enterovirus 71 from 1963 to 2019

Figures

• 

  Figure 1.. Geographical distribution of EV71 genogroups. Different colors represented the number of isolates.

• 

  Figure 2.. Phylogenetic analysis of EV71 VP1 gene sequences. The tree topology has been chosen to maximize the product of node posterior probabilities. Note: The branch colors meant the location of these strains. Branch lengths are scaled in units of time, as indicated by the time axis, with the branches colored by different countries. The thickness of the line represents the posterior probability. Thicker line represented higher posterior probability.

• 

  Figure 3A.. (A) Phylogenetic analysis of EV71 genotype B VP1 gene sequences. The tree topology has been chosen to maximize the product of node posterior probabilities. The upper left was the root location state posterior probability distributions. Note: The branch colors meant the location of these strains. Branch lengths are scaled in units of time, as indicated by the time axis with the branches colored by different countries. The thickness of the line represents the posterior probability. Thicker line represented higher posterior probability. (B) Phylogenetic analysis of EV71 genotype C VP1 gene sequences. The tree topology has been chosen to maximize the product of node posterior probabilities.

• 

  Figure 3B.. (A) Phylogenetic analysis of EV71 genotype B VP1 gene sequences. The tree topology has been chosen to maximize the product of node posterior probabilities. The upper left was the root location state posterior probability distributions. Note: The branch colors meant the location of these strains. Branch lengths are scaled in units of time, as indicated by the time axis with the branches colored by different countries. The thickness of the line represents the posterior probability. Thicker line represented higher posterior probability. (B) Phylogenetic analysis of EV71 genotype C VP1 gene sequences. The tree topology has been chosen to maximize the product of node posterior probabilities.

• 

  Figure 4.. Root state posterior probability of EV71 genotype C.

• 

  Figure 5.. Strong temporal signal tested in TempEst of EV71 genotype B (A) and genotype C (B).

• 

  Figure 6.. Bayesian skyline plots of genotype EV71 B and C, showing population size (y-axis) through time (x-axis).

• 

  Figure 7.. Spatial diffusion pathways of EV71 genotype B.

• 

  Figure 8.. Spatial diffusion pathways of EV71 subgroup C1.

• 

  Figure 9.. Spatial diffusion pathways of EV71 subgroup C2.

• 

  Figure 10.. Spatial diffusion pathways of EV71 subgroup C4.