Remarkable Antimicrobial Resistance in Nosocomial Spontaneous Bacterial Peritonitis

This is the authors' abstract. We don't add key points for this paper.

The aim of this prospective observational study was to investigate the causative agents and their susceptibility to antimicrobial drugs in patients with nosocomial spontaneous bacterial peritonitis (SBP) in order to clarify empirical antimicrobial treatment. Materials and Methods: Patients who were admitted to the Gastroenterology Department of Antalya Training and Research Hospital with prediagnosis of SBP during the period of January 2011 to December 2014 were enrolled in the study. Spontaneous bacterial peritonitis was defined as ascitic fluid with polymorphonuclear leukocyte count 250 cells/mm. Spontaneous bacterial peritonitis was considered to be nosocomial if diagnosed after >48 hours of hospitalization. During the study period, cefotaxime was the preferred empirical antimicrobial therapy in our center. If there was no clinical recovery after 48 hours or cefotaxime-resistant bacteria was identified in culture, antimicrobial therapy was switched.