Why the study?
To explore the effect of Guhong injection combined with atorvastatin on CHD patients with angina pectoris and its influence on hemorheology and oxidative stress.
Does Guhong injection combined with atorvastatin improve clinical efficacy, angina symptoms, hemorheology, and oxidative stress in patients with coronary heart disease and angina pectoris?
Does Guhong injection combined with atorvastatin improve clinical efficacy, angina symptoms, hemorheology, and oxidative stress in patients with coronary heart disease and angina pectoris?
The addition of Guhong injection to atorvastatin and standard therapy for 2 weeks significantly improved clinical symptoms, hemorheology, and oxidative stress in patients with coronary heart disease and angina pectoris.
Answers are grounded in this paper and cite their sources.
May support Guhong adjunct in angina; leaves open efficacy and safety in larger trials.
Objective: To explore the effect of Guhong injection combined with atorvastatin on CHD patients with angina pectoris and its influence on hemorheology and oxidative stress.Methods: 80 CHD patients with angina pectoris admitted to our hospital from December 2018 to December 2019 were randomly divided into the observation group (40 cases) and the control group (40 cases) by use of the random number table. The patients in the control group were treated with atorvastatin, while those in the observation group were treated with Guhong injection on the basis of the control group. The course of treatment was 2 weeks for each group. The treatment effect, the frequency of angina pectoris seizure and its duration before and after treatment, the changes of hemorheology indexes and oxidative stress and the occurrence of adverse reactions were compared between the two groups.Results: the total effective rate of the observation group (92.50%) was higher than that of the control group (70.00%) (p < .05). The frequency of angina pectoris seizure and its duration in these two groups after treatment were lower than those before treatment (Observation group: t = 25.588, 23.009; Control group: t = 16.587, 16.263; p < .05); After treatment, the frequency of angina pectoris seizure and its duration in the observation group were lower than those in the control group (t = 15.191, 9.425; p < .05). In the observation group, the hemorheology indexes after treatment were lower than those before treatment (t = 6.742, 15.224, 6.983, 23.537, p < .05); the hemorheology indexes after treatment in the observation group were lower than those in the control group (t = 5.201, 13.913, 5.539, 13.745; p < .05). In the observation group, the level of serum SOD after treatment was higher than that before treatment, while the levels of LPO and MDA after treatment were lower than those before treatment (t = 10.839, 6.924, 8.466; p < .05); the level of serum SOD after treatment in the observation group was higher than that in the control group, while the levels of LPO and MDA after treatment in the observation group were lower than those in the control group (t = 6.171, 6.432, 5.394; p < .05). The incidence of adverse reactions in the observation group was lower than that in the control group (p < .05).Conclusions: Guhong injection combined with atorvastatin has an obvious clinical effect on CHD patients with angina pectoris, and it can improve hemorheology indexes and oxidative stress reaction with fewer adverse reactions.
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Wang et al. (2021) studied this question.
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