Key result
Higher dietary polyamine intake linked to ~18% lower all-cause mortality vs lowest quintile.
Why the study?
Does dietary polyamines intake reduce all-cause mortality and incident CVD in participants without baseline CVD?
Cohort (n=184,732)
Yes
Does dietary polyamines intake reduce all-cause mortality and incident CVD in participants without baseline CVD?
Hazard Ratio: 0.82 (95% CI 0.76–0.88)
p-value: p=< 0.01
Moderate dietary polyamine intake is nonlinearly associated with a lower risk of all-cause mortality and incident cardiovascular disease, suggesting an optimal intake range.
BACKGROUND: Polyamines, including spermidine (SPD), spermine (SPM) and putrescine (PUT), are essential for cellular physiology and various cellular processes. This study aimed to examine the associations of dietary polyamines intake and all-cause mortality and incident cardiovascular disease (CVD). METHODS: This prospective cohort study included 184,732 participants without CVD at baseline from the UK Biobank who had completed at least one dietary questionnaire. Diet was assessed using Oxford WebQ, a web-based 24 h recall questionnaire, with polyamines intakes estimated from previous studies. Cox proportional models with restricted cubic splines were employed to investigate nonlinear associations. The primary endpoint was all-cause mortality or incident CVD (including CVD death, coronary heart disease and stroke). RESULTS: During a median follow-up period of 11.5 years, 7348 (3.9%) participants died and 12,316 (6.5%) developed incident CVD. Polyamines intake showed nonlinear associations with all-cause mortality and incident CVD (P for nonlinear < 0.01). Compared to the lowest quintile group of dietary polyamines intake (≤17.4 mg/day), the quintile 2 to 5 groups demonstrated a reduced risk of all-cause mortality, with the lowest risk in quintile 2 group (>17.4-22.3 mg/day) (HR:0.82, 95% CI: 0.76-0.88). Similar results were observed for incident CVD, with the lowest risk in the quintile 4 group (>27.1-33.5 mg/day) (HR: 0.86, 95% CI: 0.82-0.92). CONCLUSIONS: We found that dietary polyamines intake was associated with a lower risk of all-cause mortality or incident CVD. Furthermore, our study identified an optimal range of dietary polyamines intake.
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Su et al. (2024) conducted a cohort in General population without cardiovascular disease (n=184,732). Dietary polyamines intake vs. Lowest quintile of dietary polyamines intake (≤17.4 mg/day) was evaluated on all-cause mortality or incident CVD (including CVD death, coronary heart disease and stroke) (HR 0.82, 95% CI 0.76-0.88, p=< 0.01). Higher dietary polyamines intake was associated with a reduced risk of all-cause mortality (HR 0.82; 95% CI 0.76-0.88) and incident CVD (HR 0.86; 95% CI 0.82-0.92) compared to the lowest quintile.
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