Why the study?
Does M2-macrophage differentiation improve TREM2 modulation and amyloid-beta uptake in monocyte-derived macrophages from Alzheimer's disease patients?
Does M2-macrophage differentiation improve TREM2 modulation and amyloid-beta uptake in monocyte-derived macrophages from Alzheimer's disease patients?
Shifting the macrophage phenotype towards an M2 anti-inflammatory state increases TREM2 modulation and amyloid-beta uptake, suggesting a potential precision-medicine therapeutic avenue for Alzheimer's disease.
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Chavarría-Elizondo et al. (2022) studied this question.
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