Key result
Airway-induced lung inflammation directly triggers acute cardiovascular syndromes.
Acute and chronic lung inflammation is an underrecognized risk factor for cardiovascular disease. Yet, there are compelling epidemiological data to indicate that airway exposures to cigarette smoke, air pollution particles, and viral and bacterial pathogens are strongly related to acute ischemic events. Over the past 10 years, there have been important human and animal studies that have provided experimental evidence to support a causal link. In this article, we review the epidemiological data for the relationship between lung inflammation and cardiovascular disease and provide plausible mechanistic pathways by which acute and chronic inflammation contributes to the development of acute cardiovascular syndromes.
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Eeden et al. (2012) conducted a review in Cardiovascular disease and lung inflammation. Lung inflammation (airway exposures to cigarette smoke, air pollution particles, and pathogens) was evaluated. Acute and chronic lung inflammation from airway exposures to smoke, pollution, and pathogens is causally linked to the development of acute cardiovascular syndromes.
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