What question did this study set out to answer?

To evaluate whether nonhypertensive men with a positive two-generation family history of hypertension exhibit impaired glucose metabolism and adverse metabolic traits.

October 1, 1992HypertensionOpen Access

Increased waist/hip ratio, metabolic disturbances, and family history of hypertension.

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To evaluate whether nonhypertensive men with a positive two-generation family history of hypertension exhibit impaired glucose metabolism and adverse metabolic traits.
Recruited 16 nonhypertensive men (aged 38 ± 6 years) with a positive family history of hypertension (PFH) and 25 age-matched controls with a negative family history (NFH).
Measured resting blood pressure, anthropometric indices (BMI, waist/hip ratio, sagittal diameter), serum lipids, and erythrocyte transmembrane sodium transport.
Conducted an oral glucose tolerance test (OGTT) to assess blood glucose, plasma insulin, and C-peptide responses over 120 minutes.
Subjects with PFH had significantly higher blood pressure, body weight, BMI, waist/hip ratio, and abdominal sagittal diameter compared with NFH controls, while baseline glucose, insulin, lipids, and sodium transport showed no difference.
Blood glucose concentrations at 90 and 120 minutes, as well as plasma insulin at 90 minutes post-glucose challenge, were significantly higher in the PFH group; 90-minute glucose remained significantly associated with PFH after adjusting for BMI and waist/hip ratio.
Multivariate analysis showed waist/hip ratio significantly correlated with baseline blood pressure, insulin, and cholesterol, whereas BMI was significantly associated with the insulin response to oral glucose.

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Implication

Comparative study reveals altered glucose tolerance and elevated visceral adiposity in normotensive men with a family history of hypertension, highlighting early metabolic vulnerability.

Cite This Study

Widgren et al. (1992) studied this question.

synapsesocial.com/papers/6a6f6b915d37378ac1dc7a4e https://doi.org/10.1161/01.hyp.20.4.563

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Implication

Comparative study reveals altered glucose tolerance and elevated visceral adiposity in normotensive men with a family history of hypertension, highlighting early metabolic vulnerability.

Increased waist/hip ratio, metabolic disturbances, and family history of hypertension.

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Discussion

Implication

Cite This Study

Increased waist/hip ratio, metabolic disturbances, and family history of hypertension.

Key Points

Discussion

Implication

Cite This Study

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