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May refine models of cardiac fibroblast contractility; leaves open validation in human heart disease.
New simulations explain how mixing of actin, the most abundant protein in cells of higher organisms, with molecular motors, such as myosins, and cross-linking proteins causes cells to contract. While acto-myosin contractility is well understood for muscle cells, these new results encompass nonmuscle cells as well, providing key insights into a range of biological processes.
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Komianos et al. (2018) studied this question.
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