Key result
Vascular lineage cells resist ischemia better than neural cells, offering potential to extend stroke therapeutic windows.
Review highlights vascular cell survival after lethal ischemia in stroke models, suggesting potential to extend the therapeutic window for reperfusion therapies.
Ischemic stroke caused by cerebral artery occlusion induces neurological deficits because of cell damage or death in the central nervous system. Given the recent therapeutic advances in reperfusion therapies, some patients can now recover from an ischemic stroke with no sequelae. Currently, reperfusion therapies focus on rescuing neural lineage cells that survive in spite of decreases in cerebral blood flow. However, vascular lineage cells are known to be more resistant to ischemia/hypoxia than neural lineage cells. This indicates that ischemic areas of the brain experience neural cell death but without vascular cell death. Emerging evidence suggests that if a vascular cell-mediated healing system is present within ischemic areas following reperfusion, the therapeutic time window can be extended for patients with stroke. In this review, we present our comments on this subject based upon recent findings from lethal ischemia following reperfusion in a mouse model of stroke.
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Nakagomi et al. (2020) conducted a review in Ischemic stroke. Reperfusion therapies was evaluated. Vascular lineage cells are more resistant to ischemia than neural cells, suggesting that a vascular cell-mediated healing system following reperfusion could extend the therapeutic time window for stroke.
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