Progressive multifocal leukoencephalopathy (PML) is an often fatal opportunistic infection of the JC virus resulting in demyelination of the CNS. PML is well-described in patients with multiple sclerosis (MS) exposed to natalizumab. PML is rare in patients with myasthenia gravis (MG) and is also rare following rituximab exposure. We report PML in a patient with MG after immunosuppression that includes rituximab.
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Kanth et al. (2016) studied this question.
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