Little information is available on the stability of three-center hydrogen bonds relative to two-center hydrogen bonds. In an XHX three-center hydrogen bond, two donors interact with one acceptor; here, we compare an HXH interaction with the component two-center hydrogen bonds (H−X and X−H) in a small depsipeptide, 1 . The results show that there is negative cooperativity between the two components of the HXH interaction.
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Yang et al. (1999) studied this question.
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