A Study of North American Blastomycosis and Its Treatment With Stilbamidine and 2-Hydroxystilbamidine

Article1 November 1955A STUDY OF NORTH AMERICAN BLASTOMYCOSIS AND ITS TREATMENT WITH STILBAMIDINE AND 2-HYDROXYSTILBAMIDINEE. RICHARD HARRELL, M.D., FLORANTE C. BOCOBO, M.D., ARTHUR C. CURTIS, M.D., F.A.C.P.E. RICHARD HARRELL, M.D.Search for more papers by this author, FLORANTE C. BOCOBO, M.D.Search for more papers by this author, ARTHUR C. CURTIS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-5-1076 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStilbamidine and 2-hydroxystilbamidine are now widely accepted as the treatment of choice for the systemic fungus disease, North American blastomycosis. Schwarz and Goldman1recently reported from an epidemiologic study of blastomycosis in the United States that there were 39 cases of this disease treated with the stilbamidines during the first six months of 1953. There is a steady increase in the number of cases of blastomycosis treated with stilbamidine reported in the medical literature. These aromatic diamidines have also been used successfully in the treatment of actinomycosis2and sporotrichosis,3and have been tried (with poor results) in coccidioidomycosis,4, 5cryptococcosis6...Bibliography1. SchwarzGoldman JL: Epidemiologic study of North American blastomycosis, Arch. Dermat. 71: 84-88, 1955. CrossrefGoogle Scholar2. MillerLongSchoenbach JMPHEB: Successful treatment of actinomycosis with "stilbamidine," J. A. M. A. 150: 35 (Sept. 6) 1952. CrossrefMedlineGoogle Scholar3. HarrellBocoboCurtis ERFCAC: Sporotrichosis successfully treated with stilbamidine, Arch. Int. Med. 93: 162-164 (Jan.) 1954. CrossrefGoogle Scholar4. CohenBosWebb RJPA: Co-existing coccidioidomycosis and tuberculosis in children, Arch. Pediat. 69: 267-272 (June) 1952. MedlineGoogle Scholar5. GephardtHanlon MCTJ: Treatment of disseminated coccidioidomycosis with stilbamidine (case history), J. Oklahoma M. A. 47: 55-58 (Mar.) 1954. MedlineGoogle Scholar6. MillerSchoenbachLongShuttleworthSnider JMEBPHJSGE: Treatment of infections due to Cryptococcus neoformans with stilbamidine, Antibiotics and Chemotherapy 2: 444-446 (Sept.) 1952. Google Scholar7. ParsonsZarafonetis RJCJ: Histoplasmosis in man. A report of seven cases and a review of seventy-one cases, Arch. Int. Med. 75: 1-23 (Jan.) 1945. CrossrefGoogle Scholar8. Charr R: Histoplasmosis. Report of two cases, Am. Rev. Tuberc. 67: 376-384 (Mar.) 1953. MedlineGoogle Scholar9. CurtisHarrell ACER: Use of two stilbene derivatives (diethylstilbestrol and stilbamidine) in the treatment of blastomycosis, Arch. Dermat. and Syph. 66: 676-688 (Dec.) 1952. CrossrefGoogle Scholar10. SchwarzBaum JGL: North American blastomycosis: geographic distribution, pathology and pathogenesis, Doc. med. geog. et trop 5: 29 (Mar.) 1953. MedlineGoogle Scholar11. WilsonCawleyWeidmanGilmer JWEPFDWS: Primary cutaneous North American blastomycosis, Arch. Dermat. and Syph. 71: 39 (Jan.) 1955. CrossrefGoogle Scholar12. Smith DT: Immunologic types of blastomycosis: a report on 40 cases, Ann. Int. Med. 31: 463 (Sept.) 1949. LinkGoogle Scholar13. BocoboCurtisHarrell FCACER: In vitro fungistatic activity of stilbamidine, Propamidine, Pentamidine and Diethylstilbestrol, J. Invest. Dermat. 21: 149 (Sept.) 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Received for publication April 22, 1955.From the Department of Dermatology and Syphilology, University Hospital, University of Michigan Medical School, Ann Arbor, Michigan, and the U. S. Veterans Administration Hospital, Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Nordamerikanische BlastomykoseDie AntimykoticaTHE CURRENT STATUS OF CHEMOTHERAPY OF SYSTEMIC FUNGAL DISEASE*JOHN P. UTZ, M.D., ALBERT TREGER, M.D.North American blastomycosisTHE TOXICITY OF 2-HYDROXYSTILBAMIDINE: PROBABLE FATAL TOXIC REACTION DURING TREATMENT OF BLASTOMYCOSIS*J. WILLIAM OBERMAN, M.D., ENID F. GILBERT, M.D.Primary laryngeal blastomycosisGenitourinary Blastomycosis: Case Report and Review of LiteratureNorth American blastomycosisAminostilbamidine—A Fungistatic AgentFungus Infections of the Skin 1 November 1955Volume 43, Issue 5Page: 1076-1091KeywordsBlastomycosisDermatologyEpidemiologyFungal diseasesGranulomasPatientsSystemic diseases ePublished: 1 December 2008 Issue Published: 1 November 1955 PDF downloadLoading ...