It is known that drug substances showing no difference in absorbance along the whole gastro-intestinal (GI) tract are suitable for SR-formulations with an extended release characteristic. However, a decrease in bioavailability from proximal to distal parts of the gut may be suited for a limited retard effect. In this investigation, attempts have been made to design a suitable delivery system for captopril which is poorly bio-available from the alkaline regions of the GI-tract. The principles of ‘Bioadhesion’ as well as ‘Gastric Floating Systems’ are utilized in this study.
No takes yet. Share an insight, caveat, or question.
Matharu et al. (1992) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: