Aflatoxin B(1) binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and carcinogenicity of aflatoxin B(1) may be direct results of the affinity of this agent for DNA.
No takes yet. Share an insight, caveat, or question.
Sporn et al. (1966) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: