Why the study?
Does targeted local delivery of anti-XLF-conjugated LMWH-carrying layered double hydroxide nanoparticles reduce restenosis and thrombus formation in an animal model of injured arteries?
Does targeted local delivery of anti-XLF-conjugated LMWH-carrying layered double hydroxide nanoparticles reduce restenosis and thrombus formation in an animal model of injured arteries?
A novel antibody-targeted nanoparticle delivery system for LMWH successfully targets injured arteries and reduces restenosis and thrombus formation in an animal model.
Does not support clinical use; leaves open translation of targeted LMWH nanoparticles from animal arterial injury models.
Targeted local delivery of a nanoparticle-based, antibody-targeted, and low molecular weight heparin (LMWH) delivery system successfully reduces restenosis and thrombus formation in an animal model. An antibody recognizing cross-linked fibrin (XLF) D-dimer is successfully conjugated to layered double hydroxide nanoparticles. Use of the anti-XLF-conjugated LMWH-carrying layered double hydroxide nanoparticles shows successful targeting of the nanoparticles (red) to the injured artery wall (green), resulting in decreased neointimal thickening and thrombus formation.
No takes yet. Share an insight, caveat, or question.
Gu et al. (2012) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: