Key result
Electroporation catheter delivery markedly enhances arterial heparin retention through 12 hours versus control.
Current methods of local drug delivery frequently fail to achieve a prolonged therapeutically effective tissue drug level without producing vascular trauma. A novel double-balloon catheter system, incorporating electroporation technology, has been designed and tested to deliver heparin into rabbit carotid arteries in an overstretch balloon injury model in vivo. Following arterial injury, fluoresceinated heparin was delivered into the volume between the two inflated balloons, and the artery was subjected to an electrical pulse. Catheter deployment and endovascular electrical pulsing were well-tolerated in all animals (N = 21) without adverse hemodynamic and histological changes. Periodic arterial blood samples revealed no abnormalities in the clotting profile or any gross morphological changes in the blood cells up to 8 hr after treatment. Much stronger heparin fluorescence was detected throughout the vessel layers for at least 12 hr in the pulsed samples compared to the control. Histochemical staining of the tissue showed intracellular localization of heparin. Endovascular electroporation may provide better retention and higher therapeutic efficacy than can be achieved by conventional systemic delivery of heparin at clinically safe concentrations.
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Dev et al. (1998) studied arterial injury (n=21). Local delivery of heparin via electroporation catheter vs. Control (non-pulsed local delivery) was evaluated on Heparin tissue retention (fluorescence). Local delivery of heparin via an electroporation catheter achieved much stronger heparin fluorescence throughout the vessel layers for at least 12 hours compared to control in a rabbit injury model.
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