Squamous cell carcinoma in situ (SCCIS) of the skin is relatively common. When the authors reviewed 3846 cutaneous SCCIS cases over an 18-month period, they found 6 distinct histopathologic subtypes of SCCIS, 5 of which demonstrated multicentric variants. Multicentric variants of SCCIS were noted on nongenital and nonmucosal skin. All of the multicentric cases that were studied with p16 immunohistochemistry were positive in the tumor cells, suggesting a possible role of human papillomavirus in tumorigenesis. The authors believe that human papillomavirus likely plays a part in the development of these multicentric cutaneous SCCIS.
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Gross et al. (2015) studied this question.
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