August 1, 2008Circulation ResearchOpen Access

The Helix–Loop–Helix Factors Id3 and E47 Are Novel Regulators of Adiponectin

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Population

Differentiating adipocytes and Id3-null mice

Comparison

Alteration of Id3 and E47 expression vs Wild-type mice or undifferentiated cells

Design

Preclinical

Authors

ADAmanda C. DoranVanderbilt University NMNahum MellerCleveland Clinic Lerner College of Medicine ACAlexis CutchinsEmory University

Discussion

Member takes

Implication

Id3/E47 regulation of adiponectin in mice leaves open whether this pathway offers human cardiometabolic targets.

Structured PICO

Population

Differentiating adipocytes and Id3-null mice

Intervention

Alteration of Id3 and E47 expression (e.g., forced expression of Id3, Id3-null mice)

Comparator

Wild-type mice or undifferentiated cells

Outcome

Adiponectin expression and promoter activationsurrogate

Id3 and E47 are identified as novel regulators of SREBP-1c-mediated adiponectin expression, providing new insights into the molecular control of this atheroprotective cytokine.

Cite This Study

Doran et al. (2008) studied this question.

synapsesocial.com/papers/6a6f751d2163a0a01bc3bfad https://doi.org/10.1161/circresaha.108.175893

View Full Paper

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The Helix–Loop–Helix Factors Id3 and E47 Are Novel Regulators of Adiponectin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Helix–Loop–Helix Factors Id3 and E47 Are Novel Regulators of Adiponectin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider