January 1, 1962Public Health Reports (1896-1970)Open Access

Serodifferentiation of Poliovirus Strains for Studies of Oral Vaccine

View Full Paper

Ask AI

Bookmark

Population

Type 1 poliovirus isolates, including serial isolates from vaccinated children and 128 'wild' isolates from…

Design

Performed under code

Authors

HGHenry M. GelfandJames Madison University JNJames H. NakanoSmithsonian Institution JCJura T. ColeNational Center for Disease Control and Public Health

Discussion

Member takes

Implication

Vaccine poliovirus drift may complicate isolate attribution after week 1; leaves open the reliability of early differentiation techniques in surveillance.

Structured PICO

Population

Type 1 poliovirus isolates, including serial isolates from vaccinated children and 128 'wild' isolates from patients and healthy carriers in the United States.

Intervention

Serodifferentiation using the modified Wecker technique (plaque reduction with strain-specific antiserum).

Outcome

Mean percent plaque breakthrough (MPB) to classify strains as vaccine-like, intermediate, or non-vaccine-like.surrogate

The modified Wecker technique can differentiate vaccine-derived from wild-type poliovirus strains, though vaccine strains undergo antigenic drift during intestinal multiplication.

Cite This Study

Gelfand et al. (1962) studied this question.

synapsesocial.com/papers/6a6f765c78a11c550e092d62 https://doi.org/10.2307/4591671

View Full Paper

Ask AI

Bookmark

Implication

Vaccine poliovirus drift may complicate isolate attribution after week 1; leaves open the reliability of early differentiation techniques in surveillance.

Serodifferentiation of Poliovirus Strains for Studies of Oral Vaccine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Serodifferentiation of Poliovirus Strains for Studies of Oral Vaccine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider