Identifies NAPA-73 as a novel intermediate filament-associated protein expressed during early nervous system and heart development in chicken embryos.
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Animal data offer no clinical guidance; leaves open roles of intermediate filament proteins in vertebrate progenitor cell differentiation.
A monoclonal antibody was generated, against early neural crest-derived cells, which recognizes an epitope present on a novel intermediate filament-associated protein. This protein has been named NAPA-73 and is expressed by progenitor cells of the nervous system and heart. Biochemical and ultrastructural studies indicate that this protein associates with bundles of intermediate filaments and therefore may play a role in the determination of cell shape.
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Gary Ciment (1990) studied this question.
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