Answers are grounded in this paper and cite their sources.
Enterococcus faecalis plays a significant role in hospital-acquired infections (HAIs), and combination of penicillin with aminoglycoside is important in therapy of invasive HAIs. Penicillin resistance in this organism is due to modification of the drug target, penicillin-binding protein (PBP5), its overproduction and expression of β-lactamase. Although rare, this phenotype is often associated with multi-resistant high-risk enterococcal clonal complexes (HiRECCs), such as CC2 and CC9 which may promote its spread in the near future.
No takes yet. Share an insight, caveat, or question.
Gawryszewska et al. (2012) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: