Cyclophosphamide Inhibition of Experimental Allergic Encephalomyelitis and Cellular Transfer of the Disease in Lewis Rats

This is the authors' abstract. We don't add key points for this paper.

Single or daily injections of cyclophosphamide (CY) at appropriate dose levels completely inhibit the development of experimental allergic encephalomyelitis (EAE) in Lewis rats sensitized to spinal cord in adjuvant. CY treatment of sensitized Lewis donors or injection of CY into recipients after injection of donor lymphoid cells suppresses or inhibits transfer of EAE. Treatment of prospective recipients before injection of donor cells also may inhibit transfer. These observations, together with other data cited, suggest that active immunologic participation of the recipient may be a prerequisite for successful transfer of the disease.