What question did this study set out to answer?

To determine whether cell-surface angiotensin II receptors can induce cardiac remodeling in mice in the complete absence of angiotensin II.

January 31, 2012HypertensionOpen Access

Angiotensin II Receptor–Induced Cardiac Remodeling in Mice Without Angiotensin II

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Population

Mice without Angiotensin II

Design

Preclinical

Authors

SKSadashiva S. KarnikHeart Failure & Transplant HÜHamiyet ÜnalCleveland Clinic Lerner College of Medicine

Discussion

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Implication

Animal study reveals angiotensin II receptor-driven cardiac remodeling in mice lacking angiotensin II, suggesting ligand-independent receptor signaling causes heart disease.

Key Points

To determine whether cell-surface angiotensin II receptors can induce cardiac remodeling in mice in the complete absence of angiotensin II.
Assessed cardiac structure, function, and pathological tissue changes in genetically altered mice lacking angiotensin II.
Evaluated the baseline signaling activity of cell-surface angiotensin receptors without their endogenous activating ligand.
Angiotensin II receptor activation induced significant adverse cardiac remodeling and hypertrophy despite the total absence of angiotensin II.
Receptor-mediated downstream pathological signaling proceeded via ligand-independent mechanisms in cardiac tissue.

Structured PICO

Population

Mice without Angiotensin II

Intervention

Angiotensin II Receptor

Outcome

Cardiac remodelingsurrogate

Cite This Study

Karnik et al. (2012) studied this question.

synapsesocial.com/papers/6a6f779875498292b708dbe2 https://doi.org/10.1161/hypertensionaha.111.189423

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Implication

Animal study reveals angiotensin II receptor-driven cardiac remodeling in mice lacking angiotensin II, suggesting ligand-independent receptor signaling causes heart disease.

Angiotensin II Receptor–Induced Cardiac Remodeling in Mice Without Angiotensin II

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Angiotensin II Receptor–Induced Cardiac Remodeling in Mice Without Angiotensin II

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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