1-Desamino-8-D-arginine Vasopressin (Desmopressin) Shortens the Bleeding Time in Storage Pool Deficiency

Brief Reports1 January 19881-Desamino-8-D-arginine Vasopressin (Desmopressin) Shortens the Bleeding Time in Storage Pool DeficiencyH. KAREL NIEUWENHUIS, M.D., Ph.D., JAN J. SIXMA, M.D., Ph.D.H. KAREL NIEUWENHUIS, M.D., Ph.D., JAN J. SIXMA, M.D., Ph.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-1-65 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with congenital or acquired storage pool deficiency have a mild to moderately severe bleeding tendency, characterized by epistaxis; menorrhagia; easy bruising; and prolonged bleeding after tooth extractions, tonsillectomy, and other surgical procedures. Transfusion of normal platelets will correct the bleeding abnormality and is the treatment of choice when bleeding is life threatening. Repeated transfusions, however, often result in alloimmunization and therefore platelet transfusions are not used in minor bleeding.Gerritsen and associates (1) gave cryoprecipitate to eight patients with storage pool deficiency and prolonged bleeding times. There was a transient partial correction of the bleeding time and surgery was...References1. GERRITSEN S, AKKERMAN J, and SIXMA J. Correction of the bleeding time in patients with storage pool deficiency by infusion of cryoprecipitate. Br J Haematol. 1978;40:153-60. CrossrefMedlineGoogle Scholar2. JANSON P, JUBELIRER S, WEINSTEIN M, and DEYKIN D. Treatment of the bleeding tendency in uremia with cryoprecipitate. N Engl J Med. 1980;303:1318-22. CrossrefMedlineGoogle Scholar3. MANNUCCI P, REMUZZI G, and PUSINERI F. Deamino-8-D-arginine vasopressin shortens the bleeding time in uremia. N Engl J Med. 1983;308:8-12. CrossrefMedlineGoogle Scholar4. SAKARIASSEN K, CATTANEO M, VAN DEN BERG A, RUGGERI Z, MANNUCI P, and SIXMA J. DDAVP enhances platelet adherence and platelet aggregate growth on human artery subendothelium. Blood. 1984;64:229-36. CrossrefMedlineGoogle Scholar5. HOLMSEN H, STORM E, and DAY H. Determination of ATP and ADP in blood platelets: a modification of the firefly luciferase assay for plasma. Anal Biochem. 1972;46:489-501. CrossrefMedlineGoogle Scholar6. RAO G, WHITE J, JACHIMOWICZ A, and WITKOP C. An improved method for the extraction of endogenous platelet serotonin. J Lab Clin Med. 1976;87:129-37. MedlineGoogle Scholar7. AKKERMAN J, NIEUWENHUIS H, MOMMERSTEEG-LEAUTAUD M, GORTER G, and SIXMA J. ATP-ADP compartmentation in storage pool deficient platelets: correlation between granule-bound ADP and the bleeding time. Br J Haematol. 1983;55:135-43. CrossrefMedlineGoogle Scholar8. NIEUWENHUIS H, AKKERMAN J, and SIXMA J. Patients with a prolonged bleeding time and normal aggregation tests may have storage pool deficiency: studies on one hundred six patients. Blood. 1987;70:620-3. CrossrefMedlineGoogle Scholar9. KOBRINSKY N, ISRAELS E, and GERRARD J. Shortening of bleeding time by 1-deamino-8-D-arginine vasopressin in various bleeding disorders. Lancet. 1984;1:1145-8. CrossrefMedlineGoogle Scholar10. MANNUCCI P, VICENTE V, and VIANELLO L. Controlled trial of desmopressin in liver cirrhosis and other conditions associated with a prolonged bleeding time. Blood. 1986;67:1148-53. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: H. KAREL NIEUWENHUIS, M.D., Ph.D.; JAN J. SIXMA, M.D., Ph.D.Affiliations: University Hospital Utrecht Utrecht The Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExperience With Pre-procedural Hemostatic Medications versus Platelet Transfusion in Patients With Platelet Storage Pool DeficiencyDesmopressin (DDAVP)Hermansky-Pudlak syndrome subtype 5 (HPS-5) novel mutation in a 65 year-old with oculocutaneous hypopigmentation and mild bleeding diathesis: The importance of recognizing a subtle phenotypeInherited Platelet Function DisordersDesmopressin (DDAVP)Molecular determinants of platelet delta storage pool deficiencies: an updateTreatment of inherited platelet disordersModern management of severe platelet function disordersDesmopressin in inherited disorders of platelet functionDesmopressin (DDAVP)DDAVP normalized the bleeding time in patients with congenital platelet TxA 2 receptor abnormalityInherited defects in platelet signaling mechanismsHEMATOLOGIC MANAGEMENT OF GASTROINTESTINAL BLEEDINGPersistent Thrombopathy Causing Bleeding in 2 Domestic Shorthaired CatsPlatelet Dense GranulesReview of clinical experience of desmopressin in patients with congenital and acquired bleeding disordersMiscellaneous hormones and prostaglandinsThe Role of Pharmacologic Agents in Blood ConservationDisorders of platelet functionMiscellaneous hormones and prostaglandinsTransfusion Therapy in Acquired CoagulopathiesMiscellaneous hormones and prostaglandinsRepeated infusions of DDAVP induce low response of FVIII and vWF but not of plasminogen activatorsConsistency of responses to separate desmopressin infusions in patients with storage pool disease and isolated prolonged bleeding timeDesmopressin in the Treatment of Congenital and Acquired Defects of Platelet FunctionsClinical Efficacy of Desmopressin and Consistency of Responses to Separate Infusion in Patients with Prolonged Bleeding time Due to Congenital Platelet DefectDDAVP and Tachyphylaxis in Healthy SubjectsMyocardial Infarction and Stroke-is the Risk Increased by Desmopressin?Miscellaneous hormones and prostaglandinsFailure of DDAVP to shorten the prolonged bleeding time of two patients with congenital afibrinogenemiaDisorders of platelet functionPro: Desmopressin is of value in the treatment of post-cardiopulmonary bypass bleedingDDAVP—The Multipotent Drug in Patients With Coagulopathies2 Inherited bleeding disordersEffects of desmopressin acetate on platelet aggregation, von Willebrand factor, and blood loss after cardiac surgery with extracorporeal circulation.Congenital Disorders of Platelet FunctionPharmacology and Pharmacokinetics of Desmopressin in Haemostatic DisordersClinical Experience in Disorders of HaemostasisMiscellaneous hormones and prostaglandinsThe Hermansky-Pudlak syndrome: Variable reaction to 1-desamino-8D-arginine vasopressin for correction of the bleeding timePlatelet glass bead retention is useful in monitoring response to 1-deamino-8-D-arginine-vasopressin (d-DAVP)Hermansky-pudlak syndrome: Correction of bleeding time by 1-desamino-8D-arginine vasopressin 1 January 1988Volume 108, Issue 1Page: 65-67KeywordsHematology and oncologyHemorrhagePlateletsSurgeryVasopressin ePublished: 1 December 2008 Issue Published: 1 January 1988 PDF downloadLoading ...