Mathematical expressions are provided relating subcultivations to population doublings and population doublings to generations. Account is made for the increasing number of cells which do not attach upon subcultivation as well as the increasing number of non‐dividers. The expressions reconcile published differences in longevity and reveal that the in vitro lifetime of human diploid cells measured in cell generations is far greater than previously suspected.
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Phillip I. Good (1972) studied this question.
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