The electrochemistry of nicotinamide adenine dinucleotide (NADH) in its reduced form was examined in two room-temperature ionic liquids (RTILs): 1-ethyl-3-methylimidazolium bis-(trifluoromethylsulfonyl)imide and 1-butyl-3-methylimidazolium hexafluorophos-phate . NADH oxidation has previously been studied in aqueous solution where it follows the pathway: one-electron oxidation to the radical cation, deprotonation to produce the neutral radical, then oxidation to the cation. The electrochemistry of NADH was examined in and at the bare Pt electrode ( diameter): In , no oxidation was observed; in , an oxidative signal was observed, which likely followed the pathway described above, where upon formation of the radical cation, the anion (unlike the anion) reacts with the proton to form , which decomposes. This demonstrates the tunability of RTILs, whereby the choice of one anion in an RTIL over another can promote a reaction. Poly(vinylferrocene) (PVF) was studied as a mediator for the NADH detection in both RTILs to attempt to lower the potential of NADH detection. The Pt electrode was modified with PVF, and the oxidation of PVF to was observed in and , but no mediation of the NADH oxidation was observed.
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O’Mahony et al. (2010) studied this question.
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