July 1, 1995The Journal of PhysiologyOpen Access

Chimeric L‐type Ca2+ channels expressed in Xenopus laevis oocytes reveal role of repeats III and IV in activation gating.

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Structured PICO

Population

Xenopus laevis oocytes expressing chimeric alpha 1 subunits of L-type Ca2+ channels

Intervention

Chimeric alpha 1 subunits consisting of repeat I and II from rabbit cardiac (alpha 1C-a) and repeat III and IV from carp skeletal muscle Ca2+ channel (alpha 1S)

Comparator

Chimera consisting of repeats I, II and IV from alpha 1C-a and repeat III from alpha 1S, and a construct of repeats I to IV from alpha 1C-a

Outcome

Ba2+-current kinetics (activation and inactivation time constants)surrogate

Repeats III and IV of the L-type calcium channel alpha 1 subunit play a critical role in activation gating and inactivation kinetics.

Discussion

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Implication

Repeats III and IV determine L-type Ca channel gating; extends structure-function data but leaves open human relevance.

Cite This Study

Wang et al. (1995) studied this question.

synapsesocial.com/papers/6a6f86378031ec7bb1dbccda https://doi.org/10.1113/jphysiol.1995.sp020797

View Full Paper

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Chimeric L‐type Ca2+ channels expressed in Xenopus laevis oocytes reveal role of repeats III and IV in activation gating.

Structured PICO

Discussion

Implication

Cite This Study

Chimeric L‐type Ca2+ channels expressed in Xenopus laevis oocytes reveal role of repeats III and IV in activation gating.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider