Turnover studies with radioactive iodine‐labeled immunoglobulins ( 125 IgG and 131 IgM) and standard clinical tests were performed in 8 patients with rheumatoid arthritis before and after 2–5 months treatment with sodium‐aurothiosulphate (Sanocrysine®). Seven untreated patients served as controls. Fractional rates of catabolism and rates of synthesis of IgG and IgM were increased in all patients. After gold treatment there was a nonsignificant decrease in IgG metabolic variables, whereas IgM variables remained unchanged. The reduction in immunoglobulin metabolism correlated with clinical and serologic activity in only 1 of the 8 cases.
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Mouridsen et al. (1974) studied this question.
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