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Administration of 6-mercaptopurine and 6-thioguanine decreased serum gamma globulin concentrations in rabbits and produced an increase in concentration of a β2 protein as measured by agar and paper electrophoresis. Immunoelectrophoretic studies confirmed the increase in the β2 globulin and allowed detection of a “γx” precipitin line which was masked by the gamma globulin precipitin line prior to treatment.
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Wolff et al. (1963) studied this question.
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