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Summary Results on the biweekly plasmapheresis for 1 yr on each of 23 donors have demonstrated the safety and feasibility of the method utilizing the ADL-Cohn Fractionator. Bacterial and viral antibodies have persisted at peak levels for almost 2 yr following the administration of antigen, despite the fact that the donors were not subjected to plasmapheresis the 2nd year. A rationale for antibody production by plasmapheresis is presented. Theoretic and practical considerations are discussed.
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Smolens et al. (1957) studied this question.
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