Key result
Induced pluripotent stem cell-derived endothelial cells show regenerative potential, assessed by in vivo vessel formation.
The emergence of induced pluripotent stem cell (iPSC) technology paves the way to generate large numbers of patient-specific endothelial cells (ECs) that can be potentially delivered for regenerative medicine in patients with cardiovascular disease. In the last decade, numerous protocols that differentiate EC from iPSC have been developed by many groups. In this review, we will discuss several common strategies that have been optimized for human iPSC-EC differentiation and subsequent studies that have evaluated the potential of human iPSC-EC as a cell therapy or as a tool in disease modeling. In addition, we will emphasize the importance of using in vivo vessel-forming ability and in vitro clonogenic colony-forming potential as a gold standard with which to evaluate the quality of human iPSC-EC derived from various protocols.
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Lin et al. (2017) conducted a review in Cardiovascular disease. Human Induced Pluripotent Stem Cell-Derived Endothelial Cells was evaluated. Human induced pluripotent stem cell-derived endothelial cells hold potential for cardiovascular regenerative medicine, with in vivo vessel-forming ability serving as a gold standard for evaluation.
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