In 1926 Minot and Isaacs 1 published a paper on lymphoblastoma. By that term they meant to include leukemia, Hodgkin's disease, lymphosarcoma and allied disorders. After a careful statistical study of 477 cases they came to the conclusion that all these diseases were incurable. They found that about 10 per cent of the patients had had the disease for six years or longer. Although a number of patients who survived for a long time had been treated by roentgen rays, surgery or a combination of the two, there were some who had received no curative treatment, and the authors felt that it was not possible to conclude that any had been cured by treatment even though they could not deny definite amelioration in some cases. Since that time there have been remarkably few studies of the results of treatment of this group as a whole, and of lymphosarcoma in particular.
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Arthur Purdy Stout (1942) studied this question.