This preclinical study describes an experimental model evaluating a 1-mm PTFE microprosthesis as an aortic substitute in rats compared to biological grafts.
The experimental behavior of a 1-mm internal diameter (i.d.) polytetrafluoroethylene (PTFE) microprosthesis, as a substitute for an abdominal aortic segment in the rat, was reviewed. Fifty Wistar rats were divided into four groups: Group I - 12 rats with autotransplant of an abdominal aortic segment (AAS); Group II - 12 rats with allotransplant of an AAS obtained from Long-Evans rats; Group III - 12 rats with xeno-transplant of an AAS taken from rabbit femoral arteries; and Group IV - 14 rats with substitution of an AAS by a 1-mm i.d. PTFE microprosthesis. The rats were sacrificed at different time intervals ranging from five to 360 days, with previous aortography.
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Padilla et al. (1987) studied this question.
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