Treatment of Adult Acute Nonlymphocytic Leukemia—1980

Editorials1 July 1980Treatment of Adult Acute Nonlymphocytic Leukemia—1980CLARA D. BLOOMFIELD, M. D.CLARA D. BLOOMFIELD, M. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-1-133 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptImpressive advances in the treatment of adult acute nonlymphocytic leukemia have occurred during the last 10 years. The percentage of patients achieving complete remission has increased. The median durations of these remissions have lengthened, and the percentage of longterm survivors has risen. Ten years ago, a 25% remission rate for adults was exceptional. Today complete remission rates of more than 50% are regularly achieved in large cooperative group trials (1,2), and using combinations that include an anthracycline antibiotic (daunorubicin hydrochloride or doxorubicin hydrochloride), cytarabine, and 6-thioguanine or 6-mercaptopurine, complete remission rates of more than 80% have been reported by several...References1. YATESGLIDEWELLWIERNIKHOLLAND JOPJ. A CALGB study of adriamycin vs daunorubicin induction and a four vs eight week maintenance in acute myelocytic leukemia. Proc Am Soc Clin Oncol. 1980;21:350. Abstract. Google Scholar2. BENNETTBEGGSARTIANOTARTAGLIACARBONE JCGAP. The chemotherapy of adult acute myeloid leukemia. Proc Am Soc Clin Oncol. 1980;21:434. Abstract. Google Scholar3. UZUKALIONGYAMAGATA YSS. Treatment of adult acute nonlymphoblastic leukemia using intermittent combination chemotherapy with daunomycin, cytosine arabinoside, 6-mercaptopurine and prednisolone-DCMP two step therapy. Tohoku J Exp Med. 1976; 118(suppl):217-25. CrossrefMedlineGoogle Scholar4. GALECLINE RM. High remission-induction rate in acute myeloid leukaemia. Lancet. 1977;1:497-9. CrossrefMedlineGoogle Scholar5. REESHAYHOE JF. D. A.T. (daunorubicin, cytarabine, 6-thioguanine) in acute myeloid leukaemia. Lancet. 1978;1:1360-1. Letter. CrossrefMedlineGoogle Scholar6. PETERSONBLOOMFIELDBOSLGIBBSMALLOY BCGGM. Rapid remission induction with intensive chemotherapy in adult acute nonlymphocytic leukemia. Blood. 1978;52(suppl):269. Abstract. Google Scholar7. PETERSONBLOOMFIELD BC. Treatment of acute nonlymphocytic leukemia in elderly patients. Cancer. 1977;40:647-52. CrossrefMedlineGoogle Scholar8. GALEZIGHELBOIMFOONCLINE RJKM. Intensive chemoimmunotherapy in acute myelogenous leukemia. Blood. 1978;52(suppl 1):250. Abstract. Google Scholar9. ARLINGEEFRIEDKOENIGSBERGWOLMARKCLARKSON ZTJENB. Rapid induction of remission in acute nonlymphocytic leukemia. Proc Am Assoc Cancer Res. 1979;20:112. Abstract. Google Scholar10. LEGHAKEATINGZANDERMCCREDIEBODEYFREIREICH SMAKGE. 4′-(9-acridinylamino) methanesulfon-m-anisidide (AMSA): a new drug effective in the treatment of adult acute leukemia. Ann Intern Med. 1980;93:17-21. LinkGoogle Scholar11. SAUTERALBERTOBERCHTOLDCAVALLIFOPPTSCHOPP CPWFML. Three to five month's remission induction treatment of acute myelogenous leukemia followed by maintenance treatment or no maintenance treatment. Proc Am Soc Clin Oncol 1980;21:433. Abstract. Google Scholar12. PETERSONBLOOMFIELD BC. Prolonged maintained remissions of adult acute non-lymphocytic leukaemia. Lancet. 1977;2:158-60. CrossrefMedlineGoogle Scholar13. COLTMANBODEYHEWLETT CGJ. Chemotherapy of acute leukemia: a comparison of vincristine, cytarabine, and prednisone alone and in combination with cyclophosphamide or daunorubicin. Arch Intern Med. 1978;138:1342-8. CrossrefMedlineGoogle Scholar14. PREISLERBROWMANHENDERSONHRYNIUKFREEMAN HGEWA. Treatment of acute myelocytic leukemia: effects of early intensive consolidation. Proc Am Soc Clin Oncol. 1980;21:443. Abstract. Google Scholar15. BURCHENAL J. Formal discussion: long-term survival in Burkitt's tumor and in acute leukemia. Cancer Res 1967;27:2616-8. MedlineGoogle Scholar16. KEATINGBODEYMCCREDIEFREIREICH MGKE. Five-year survival and remission duration in adult acute myelogenous leukemia. Proc Am Soc Clin Oncol. 1979;20:416. Abstract. Google Scholar17. PETERSONBLOOMFIELD BC. Prolonged disease-free survival in adult acute non-lymphocytic leukemia. Proc Am Soc Clin Oncol. 1979;20:441. Abstract. Google Scholar18. COLTMANFREIREICHSAVAGEGEHAN CERE. Long term survival of adults with acute leukemia. Proc Am Soc Clin Oncol. 1979;20:389. Abstract. Google Scholar19. KEATINGSMITHGEHAN MTE. Factors related to length of complete remission in adult acute leukemia. Cancer. 1980;45:2017-29. CrossrefMedlineGoogle Scholar20. ODOMROSETUBERGEN LBD. A successful induction regimen for childhood acute nonlymphoblastic leukemia. Proc Am Soc Clin Oncol 1979;20:440. Abstract. Google Scholar21. THOMASBUCKNERCLIFT ECR. Marrow transplantation for acute nonlymphoblastic leukemia in first remission. N Engl J Med. 1979;301:597-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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BLUME, M.D. 1 July 1980Volume 93, Issue 1_Part_1Page: 133-135KeywordsAcute myeloid leukemiaAntibiotics Issue Published: 1 July 1980 PDF DownloadLoading ...