Antibody response in 89 patients with typhoid and paratyphoid fever was related to therapy with chloramphenicol and ampicillin. Both maximum titers and significant changes in titers (as measured by the Widal reaction) were compared in the two drug groups. In enteric fever, chloramphenicol did not consistently and significantly inhibit antibody formation as has been described in experimental infection, nor could complications of enteric fever be related to inhibition of antibody formation in either group. Chloramphenicol does not inhibit antibody formation in enteric fever to a greater degree than any effective mode of therapy, and the popular hypothesis of chloramphenicol inhibition of antibody formation in enteric fever is erroneous.
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Robertson et al. (1970) studied this question.
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