Management of Antibiotic-Resistant Neisseria gonorrhoeae

Editorials1 January 1989Management of Antibiotic-Resistant Neisseria gonorrhoeaeFranklyn N. Judson, MDFranklyn N. Judson, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-1-5 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBecause man is the only natural host of the species Neisseria gonorrhoeae, the ability of the gonococcus to thrive in a hostile antibiotic world serves as testimony both to the genetic principles of natural selection and to the unwillingness of its human host to limit sexual contacts to long-term mutually monogamous relationships.From 1945 to 1954, the first decade that penicillin was used to treat gonorrhea, antimicrobial resistance and treatment failures were extremely rare. Even the smallest doses of penicillin, tetracycline, or chloramphenicol eradicated the helpless gonococcus, and a movement by ecologists of the day to placeN. gonorrhoeaeon...References1. MartinLesterPriceSchmale JAEJ. Comparative study of gonococcal susceptibility to penicillin in the United States, 1955-1969. J Infect Dis. 1970;122:459-61. CrossrefMedlineGoogle Scholar2. ReynoldsZaidiThornsberry GAC. The National Gonorrhea Therapy Monitoring Study. II. Trends and seasonality of antibiotic resistance of Neisseria gonorrhoeae. Sex Transm Dis. 1979;6(Suppl.):103-11. CrossrefMedlineGoogle Scholar3. FarukiKohmescherMcKinneySparling HRWP. A community-based outbreak of infection with penicillin-resistant Neisseria gonorrhoeae not producing penicillinase (chromosomally mediated resistance). N Engl J Med. 1985;313:607-11. CrossrefMedlineGoogle Scholar4. RiceBiddleJean LouisDeWittBlountMorse RJYWJS. Chromosomally mediated resistance in Neisseria gonorrhoeae in the United States: results of surveillance and reporting, 1983-84. J Infect Dis. 1986;153:340-5. CrossrefMedlineGoogle Scholar5. Penicillinase-producing Neisseria gonorrhoeae—United States, 1986. MMWR. 1987;36:107-8. MedlineGoogle Scholar6. Multiple strain outbreak of penicillinase-producing Neisseria gonorrhoeae—Denver, Colorado, 1986. MMWR. 1987;36:534-43. MedlineGoogle Scholar7. KnappZenilmanBiddle JJJ. Frequency and distribution in the United States of strains of Neisseria gonorrhoeae with plasmid-mediated, high-level resistance to tetracycline. J Infect Dis. 1987;155:819-22. CrossrefMedlineGoogle Scholar8. MorseJohnsonBiddleRoberts SSJM. High-level tetracycline resistance in Neisseria gonorrhoeae is result of acquisition of streptococcal tetM determinant. Antimicrob Agents Chemother. 1986;30:664-70. CrossrefMedlineGoogle Scholar9. RobertsKnapp MJ. Host range of the conjugative 25.2-megadalton tetracycline resistance plasmid from Neisseria gonorrhoeae and related species. Antimicrob Agents Chemother. 1988;32:488-91. CrossrefMedlineGoogle Scholar10. BoslegoTramontTakafuji JEE. Effect of spectinomycin use on the prevalence of spectinomycin-resistant and of penicillinase-producing Neisseria gonorrhoeae. N Engl J Med. 1987; 317:272-8. CrossrefMedlineGoogle Scholar11. ZenilmanNimsMenegusNolteKnapp JCMFJ. Spectinomycin-resistant gonococcal infections in the United States, 1985-1986. J Infect Dis. 1987;156:1002-4. CrossrefMedlineGoogle Scholar12. Antibiotic-resistant strains of Neisseria gonorrhoeae. Policy guidelines for detection, management, and control. MMWR. 1987;36(Suppl. 5S):1S-18S. MedlineGoogle Scholar13. Sentinel surveillance system for antimicrobial resistance in clinical isolates of Neisseria gonorrhoeae. MMWR. 1987;36:585-92. MedlineGoogle Scholar14. 1985 STD Treatment Guidelines. MMWR. 1985;34(Suppl. 4S): 75S-108S. MedlineGoogle Scholar15. JudsonEhretHandsfield FJH. Comparative study of ceftriaxone and spectinomycin for treatment of pharyngeal and anorectal gonorrhea. JAMA. 1985;253:1417-9. CrossrefMedlineGoogle Scholar16. Judson F. Treatment of uncomplicated gonorrhea with ceftriaxone: a review. Sex Transm Dis. 1986;13:199-202. CrossrefMedlineGoogle Scholar17. HandsfieldHook HE. Ceftriaxone for treatment of uncomplicated gonorrhea: routine use of a single 125-mg dose in a sexually transmitted disease clinic. Sex Transm Dis. 1987;14:227-30. CrossrefMedlineGoogle Scholar18. Judson F. Fear of AIDS and incidences of gonorrhea, syphilis, and hepatitis B, 1982-87 [Abstract]. IV International Conference on AIDS, June 12-16, 1988, Stockholm, Sweden. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Colorado and Denver Disease Control Service Denver, Colorado PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGonococia genital femeninaMolecular Epidemiology of Infections With Neisseria gonorrhoeae Among Visitors to a Sexually Transmitted Diseases ClinicAntimicrobial Susceptibility and Types of Neisseria gonorrhoeae in GreeceG UINEA -B ISSAU'S P LANTS: IN VITRO S USCEPTIBILITY S TUDIES ON N EISSERIA GONORRHOEAEAntibiotic use in the emergency department. IV: Single-dose therapy and parenteral-loading dose therapyDiagnostic biologique des MST chez la femmeAntimicrobial susceptibility testing of Neisseria gonorrhoeae and implications for epidemiology and therapyTreatment of Acute Gonococcal Infections in Bangkok with a Dose Range of the New Cephalosporin, CefodizimeThe epidemiology of Neisseria gonorrhoeae isolates in Dakar, Senegal 1982-1986: antimicrobial resistance, auxotypes and plasmid profiles.Oral ciprofloxacin versus ceftriaxone for the treatment of urethritis from resistant Neisseria gonorrhoeae in ZambiaDifferent doses of cefetamet pivoxil (Ro 15-8075) in the treatment of acute uncomplicated gonococcal urethritis in menGonorrhea 1 January 1989Volume 110, Issue 1Page: 5-7KeywordsAntibioticsAntimicrobial resistanceChloramphenicolGeneticsGonorrheaNeisseria gonorrhoeaePenicillinPrevention, policy, and public healthTetracyclines Issue Published: 1 January 1989 PDF DownloadLoading ...