Why the study?
Lactate measurement can predict mortality in acute type A aortic dissection, but discriminatory power varies across studies and no reliable cut-off point has been defined.
Does lactate measurement predict mortality in patients presenting with acute type A aortic dissections?
Does lactate measurement predict mortality in patients presenting with acute type A aortic dissections?
Lactate levels may serve as a simple and universally available tool to predict mortality in acute type A aortic dissection, though further research is needed to define optimal cut-off values.
Lactate may aid risk stratification in type A dissection when combined with other markers; leaves open optimal cut-offs and prospective validation.
Lactate levels are surrogate markers of malperfusion in patients presenting with type A aortic dissections. Lactate measurement is simple, easy to perform, universally available, and thus can be an important tool for predicting mortality. However, the discriminatory power varies between studies and no cut-off point has been defined that can determine outcomes in the most reliable fashion. The risk prediction based on lactate levels can be improved when combined with other clinical and laboratory prognostic factors. Further studies with a much larger sample size, need to be carried out using serial measurements at well-defined time points to try and identify a cut-off value. The addition of lactate values to existing risk prediction scores or developing a new score based on it should be the subject of future research.
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Shetty et al. (2022) studied this question.
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