Why the study?
Does angiotensin II inhibit insulin-stimulated phosphorylation of 4E-BP1 and protein synthesis in renal proximal tubular epithelial cells?
Population
Renal proximal tubular epithelial cells
Comparison
Pre-incubation with angiotensin II followed by… vs Insulin alone or angiotensin II alone
Design
Preclinical
Authors
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Hypothesis-generating for angiotensin II-driven tubular insulin resistance; in vivo studies needed before clinical relevance.
Does angiotensin II inhibit insulin-stimulated phosphorylation of 4E-BP1 and protein synthesis in renal proximal tubular epithelial cells?
Angiotensin II inhibits insulin-stimulated protein synthesis and 4E-BP1 phosphorylation in renal cells, providing a mechanistic basis for angiotensin II-induced insulin resistance.
Duraisamy et al. (2001) studied this question.
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