Why the study?
Generating biologically plausible synthetic ECG examples is challenging due to complex dynamic biological-physiological interactions, motivating the integration of mathematical heart simulators into generative models to improve classification.
Incorporating mathematical process simulators (ODEs) into Generative Adversarial Networks improves the generation of synthetic ECGs, thereby enhancing deep learning-based heartbeat classification.
Synthetic ECG generation may augment scarce training data for heartbeat classification; leaves open prospective clinical validation.
Generating training examples for supervised tasks is a long sought after goal in AI. We study the problem of heart signal electrocardiogram (ECG) synthesis for improved heartbeat classification. ECG synthesis is challenging: the generation of training examples for such biological-physiological systems is not straightforward, due to their dynamic nature in which the various parts of the system interact in complex ways. However, an understanding of these dynamics has been developed for years in the form of mathematical process simulators. We study how to incorporate this knowledge into the generative process by leveraging a biological simulator for the task of ECG classification. Specifically, we use a system of ordinary differential equations representing heart dynamics, and incorporate this ODE system into the optimization process of a generative adversarial network to create biologically plausible ECG training examples. We perform empirical evaluation and show that heart simulation knowledge during the generation process improves ECG classification.
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Golany et al. (2020) studied this question.
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