BENcE-JONES protein, which is characterized by precipitation from solution at low temperatures (45-50') and resolution of the coagulum on boiling, is excreted in the urine in about 70 % of the cases of multiple myelomatosis.and occasionally also in allied diseases of the bone marrow and blood-forming organs. Of some seven hundred papers on myelomatosis which have appeared since Bence-Jones [1848] first noted the excretion of a peculiar substance in a case of 'mollities ossium', relatively few have dealt in detail with the chemistry of the protein.
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John Devine (1941) studied this question.
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