Irritability was tested in mice reared in four environmental conditions: impoverished (IC), impoverished + overstimulated (ICS), enriched (EC), and enriched + overstimulated (ECS) conditions. The test used was a modified "bottle brush" test. Both overstimulations and individual housing increased irritability interacting positively with each other. Individual housing but not overstimulation decreased avoidance behavior in the mice.
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Riittinen et al. (1986) studied this question.
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