Introduction Osteosarcoma (OS) is the most common primary malignant bone tumour in children and adolescents. The gold standard for therapy consists of a combination of multi-agent neoadjuvant chemotherapy, followed by radical surgery and adjuvant chemotherapy. With this aggressive regimen, 5-year survival rates of approximately 65% are obtained in patients with localised
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PosthumaDeBoer et al. (2013) studied this question.
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