Key result
Methylglyoxal is implicated in hypertension development via mechanisms linked to vascular damage.
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Hypertension is a life-threatening disease that is associated with increased cardiovascular risks. Causes and mechanisms for hypertension development remain poorly understood. Methylglyoxal (MG), a highly reactive molecule, is a metabolite of sugar. Increased circulation and tissue levels of MG have been documented not only in diabetes but also in hypertension. Many recent studies also link MG-induced vascular damage to the pathogenic process of hypertension. As such, an etiological role of MG in hypertension development is proposed.
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Lingyun Wu (2006) conducted a review in Hypertension. Methylglyoxal was evaluated. Methylglyoxal is proposed to have an etiological role in the development of hypertension due to its association with vascular damage.
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