Key result
Cell, gene, and tissue therapies advance novel approaches for myocardial salvage and post-infarct repair.
Cardiac tissue reconstruction following myocardial infarction represents a major challenge in cardiovascular therapy, as current clinical approaches are limited in their ability to regenerate or replace damaged myocardium. Thus, different novel treatments have been introduced aimed at myocardial salvage and repair. Here, we present a review of recent advancements in cardiac cell, gene-based and tissue engineering therapies. Selected strategies in cell therapy and new tools for myocardial gene transfer are summarized. Finally, we consider novel approaches to myocardial tissue engineering as a platform for the integration of various modalities in an attempt to rejuvenate infarcted tissue in vivo.
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Ruvinov et al. (2008) conducted a review in Myocardial infarction. Cardiac cell, gene-based, and tissue engineering therapies was evaluated. Recent advancements in cardiac cell, gene-based, and tissue engineering therapies offer novel approaches aimed at myocardial salvage, repair, and in vivo rejuvenation of infarcted tissue.
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