Why the study?
Does a positive patch test to nickel predict adverse clinical outcomes following atrial septal defect closure with a nickel alloy-based device?
Does a positive patch test to nickel predict adverse clinical outcomes following atrial septal defect closure with a nickel alloy-based device?
A positive nickel patch test does not appear to predict adverse clinical outcomes or device failure in patients undergoing ASD closure with nitinol devices.
Answers are grounded in this paper and cite their sources.
May not warrant avoiding nitinol ASD closure based on nickel patch testing; leaves open larger prospective studies.
BACKGROUND: Patch testing is thought to be necessary prior to metal device implantation to rule out metal allergy-related complications; however, there are controversies over the effects of nickel allergy on the outcome of nickel alloy-based device implantation. OBJECTIVE: This study aimed to evaluate the adverse events in a Korean population of nickel allergy patients who underwent atrial septal defect (ASD) closure with a nickel-titanium alloy-based device. METHODS: We retrospectively reviewed the medical records of patients who underwent ASD closure with a nitinol device. RESULTS: Among 38 patients who had ASD closure, 4 of 5 nickel-allergic patients and 10 of the 33 non-nickel-allergic patients had post-closure complications. All patients fared well, without device failure culminating in device removal. CONCLUSION: In this study, positive reactions to nickel in a patch test were not associated with adverse early or late outcomes following ASD closure with a nickel alloy-based device.
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Kim et al. (2015) studied this question.
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